Regulation of protein localization to chromatin

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAG1, LMOD1, and NEIL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to chromatin activity versus IRAG1 in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRAG1 →	-0.949	-0.853	<.001	<.001	3	6
GBM	LMOD1 →	-0.709	-1.218	<.001	<.001	3	5
UCEC	NEIL3 →	+0.845	+0.683	<.001	.006	3	4
UCEC	TIMELESS →	+0.541	+0.513	.002	.005	3	4
HNSC	DCN →	-0.964	-0.609	.005	.005	3	4
UCEC	NDN →	-0.724	-0.489	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905634 vs IRAG1 — UCEC

Explore this scatter interactively →