Regulation of protein localization to chromatin

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF5, NCAPD2, and ADSL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF5 grouped by Regulation of protein localization to chromatin-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TAF5 →	-0.729	-0.170	.001	.002	3	6
STOMACH	NCAPD2 →	-0.823	-0.298	.007	.002	3	5
SKIN	ADSL →	-0.621	-0.222	.001	.001	3	5
PANCREAS	SGO1 →	-0.805	-0.209	.006	.009	2	6
PANCREAS	ZNF618 →	-1.528	-0.281	.001	.002	3	5
KIDNEY	XRCC6 →	-0.671	-0.215	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF5 by Regulation of protein localization to chromatin activity — OVARY

Explore this box plot interactively →