Positive regulation of blood-brain barrier permeability

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood-brain barrier permeability pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, TJP1, and RALGAPA2, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood-brain barrier permeability activity versus TJP2 in UCS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	TJP2 →	+1.632	+0.109	<.001	<.001	3	30
UVM	TJP1 →	+1.066	+0.054	<.001	<.001	3	26
ESCA	RALGAPA2 →	+1.429	+0.118	<.001	<.001	3	24
CHOL	CLCN3 →	+1.368	+0.134	.001	<.001	2	24
UCS	SH3RF1 →	+1.386	+0.118	<.001	.001	3	23
CHOL	RAB11FIP1 →	+1.790	+0.140	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905605 vs TJP2 — UCS

Explore this scatter interactively →