Positive regulation of blood-brain barrier permeability

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood-brain barrier permeability pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA5, TOX3, and GPD1L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood-brain barrier permeability activity versus LILRA5 in UCEC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LILRA5 →	-0.925	-1.018	<.001	<.001	3	8
PDAC	TOX3 →	+0.582	+0.511	.001	.009	3	6
BRCA	GPD1L →	+0.819	+0.564	.001	<.001	3	6
UCEC	ANKFN1 →	+1.161	+0.842	.004	<.001	3	6
UCEC	FPR2 →	-0.794	-0.756	.001	.001	3	6
BRCA	ARL4C →	-0.843	-0.717	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905605 vs LILRA5 — UCEC

Explore this scatter interactively →