Regulation of blood-brain barrier permeability

Across TCGA patient cohorts, RNA activity of the Regulation of blood-brain barrier permeability pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TJP3, TJP3_S203, and TJP3_S368, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood-brain barrier permeability activity versus TJP3 in LSCC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TJP3 →	+0.576	+0.103	<.001	<.001	3	5
LSCC	TJP3_S203 →	+0.895	+0.090	<.001	<.001	3	5
PDAC	TJP3_S368 →	+0.657	+0.078	<.001	<.001	3	5
LSCC	DDX27 →	-0.391	-0.078	<.001	<.001	3	5
OV	ARHGEF10L →	+0.359	+0.055	.002	.001	3	5
LSCC	TJP3_S112 →	+0.514	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905603 vs TJP3 — LSCC

Explore this scatter interactively →