Regulation of blood-brain barrier permeability

Across TCGA cell cohorts, RNA activity of the Regulation of blood-brain barrier permeability pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFA, ZEB2, and TPSD1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFA grouped by Regulation of blood-brain barrier permeability-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VEGFA →	-0.342	-1.438	<.001	<.001	3	16
BLOOD_Leukemia	ZEB2 →	-0.470	-1.102	<.001	<.001	3	8
OVARY	TPSD1 →	-0.221	-1.258	<.001	.006	3	4
BLOOD_Lymphoma	PHF11 →	-0.433	-1.609	.002	.007	2	5
UPPER_AERODIGESTIVE_TRACT	PARP12 →	-0.141	-0.788	.002	.003	3	4
BLOOD_Leukemia	GLUD2 →	+0.172	+0.862	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFA by Regulation of blood-brain barrier permeability activity — OVARY

Explore this box plot interactively →