Regulation of blood-brain barrier permeability

Across TCGA cell cohorts, RNA activity of the Regulation of blood-brain barrier permeability pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, PC, and TJP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood-brain barrier permeability activity versus TJP2 in OESOPHAGUS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TJP2 →	+1.466	+0.596	<.001	.009	3	5
SOFT_TISSUE	PC →	-1.526	-1.678	.004	<.001	3	4
BREAST	TJP1 →	+1.344	+1.508	<.001	<.001	3	4
BREAST	TMEM123 →	+1.257	+1.012	.003	.006	3	4
LUNG_NSCLC_LUAD	MUC4 →	+2.463	+0.489	.003	.009	3	4
LUNG_NSCLC_LUAD	TUB →	-1.398	-0.525	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905603 vs TJP2 — OESOPHAGUS

Explore this scatter interactively →