Positive regulation of vascular endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC11A, COX4I2, and RNF6P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial cell proliferation activity versus CLEC11A in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLEC11A →	+0.963	+0.201	.007	.007	3	5
CCRCC	COX4I2 →	+0.631	+0.114	.009	.002	3	4
CCRCC	RNF6P1 →	-0.012	-0.210	.005	.003	3	4
LSCC	EXT2 →	+0.339	+0.173	.002	.001	3	4
OV	JAM3 →	+0.699	+0.211	.002	<.001	3	4
OV	TCEAL7 →	+0.755	+0.174	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905564 vs CLEC11A — OV

Explore this scatter interactively →