Positive regulation of vascular endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX60, RTP4, and FKBP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX60 grouped by Positive regulation of vascular endothelial cell proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DDX60 →	-1.072	-0.710	.008	.005	3	4
PANCREAS	RTP4 →	-1.434	-0.662	<.001	.002	3	4
LIVER	FKBP4 →	+0.733	+0.502	.001	<.001	3	4
LARGE_INTESTINE	PHLDA1 →	-2.055	-0.815	<.001	.003	3	3
LARGE_INTESTINE	HS3ST1 →	-1.052	-0.789	.003	.004	3	3
LARGE_INTESTINE	OTUB2 →	-1.145	-0.834	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX60 by Positive regulation of vascular endothelial cell proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →