Positive regulation of vascular endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF263, ZNF500, and PDPK1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial cell proliferation activity versus ZNF263 in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF263 →	+0.684	+0.091	<.001	<.001	3	12
CNS	ZNF500 →	+0.562	+0.074	<.001	.001	3	12
BLOOD_Lymphoma	PDPK1 →	+0.858	+0.100	<.001	.001	2	12
BREAST	ZNF646 →	+0.756	+0.089	<.001	<.001	3	11
CNS	VPS39 →	+0.542	+0.111	<.001	<.001	3	11
BLOOD_Leukemia	CREBBP →	+0.804	+0.084	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905564 vs ZNF263 — BREAST

Explore this scatter interactively →