Positive regulation of vascular endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFDP1, HMGB1, and RPL21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial cell proliferation activity versus TFDP1 in LUNG_SCLC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TFDP1 →	+1.043	+0.251	.007	<.001	3	5
LUNG_SCLC	HMGB1 →	+0.646	+0.310	<.001	.009	3	5
BLOOD_Lymphoma	RPL21 →	+0.549	+0.117	.004	.001	3	4
LUNG_NSCLC_LUAD	FGF2 →	-2.568	-0.383	<.001	.001	3	4
BLOOD_Myeloma	LPIN1 →	-1.721	-0.375	.004	.003	3	4
UPPER_AERODIGESTIVE_TRACT	FBL →	+0.825	+1.256	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905564 vs TFDP1 — LUNG_SCLC

Explore this scatter interactively →