Negative regulation of vascular endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL2, PECAM1, and ARHGDIB, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular endothelial cell proliferation activity versus CCL2 in KICH (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	CCL2 →	+1.914	+0.085	<.001	<.001	3	23
ESCA	PECAM1 →	+1.487	+0.092	<.001	<.001	3	23
PCPG	ARHGDIB →	+1.056	+0.073	<.001	<.001	3	22
SCLC	GMFG →	+1.127	+0.538	<.001	.001	2	23
MESO	CYYR1 →	+0.970	+0.061	<.001	.001	3	22
PCPG	CLEC14A →	+1.066	+0.062	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905563 vs CCL2 — KICH

Explore this scatter interactively →