Negative regulation of vascular endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular endothelial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EHD2, MMRN2, and KIF15_S568, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular endothelial cell proliferation activity versus EHD2 in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EHD2 →	+0.376	+0.071	<.001	.001	3	6
UCEC	MMRN2 →	+0.441	+0.078	.001	.003	3	6
LUAD	KIF15_S568 →	-0.614	-0.070	<.001	<.001	3	6
UCEC	TBC1D2B →	+0.325	+0.093	<.001	.004	3	5
HNSC	ARHGAP24_S415 →	+0.594	+0.061	<.001	<.001	3	5
CCRCC	SHANK3 →	+0.442	+0.084	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905563 vs EHD2 — LUAD

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