Negative regulation of vascular endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are A2M, IL16, and P2RY8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular endothelial cell proliferation activity versus A2M in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	A2M →	+0.908	+0.535	<.001	<.001	3	6
HNSC	IL16 →	+0.615	+0.663	<.001	<.001	3	5
LSCC	P2RY8 →	+0.715	+0.521	<.001	<.001	3	5
HNSC	MEF2C →	+0.898	+0.748	<.001	<.001	3	5
GBM	ITGA4 →	+1.081	+0.643	<.001	<.001	3	5
LSCC	LAX1 →	+1.148	+0.792	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905563 vs A2M — LSCC

Explore this scatter interactively →