Negative regulation of macrophage migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage migration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRPV2, RCSD1, and SASH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage migration activity versus TRPV2 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRPV2 →	+0.414	+0.073	<.001	<.001	3	8
HNSC	RCSD1 →	+0.533	+0.082	<.001	<.001	3	8
LSCC	SASH3 →	+0.436	+0.078	<.001	<.001	3	8
BRCA	SEPTIN1 →	+0.788	+0.057	<.001	<.001	3	8
BRCA	WAS →	+0.485	+0.040	<.001	<.001	3	8
BRCA	WIPF1 →	+0.415	+0.057	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905522 vs TRPV2 — HNSC

Explore this scatter interactively →