Negative regulation of macrophage migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPP3, TAFA5, and FBXL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage migration activity versus PLPP3 in GBM (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLPP3 →	+0.517	+0.187	<.001	.003	3	5
HNSC	TAFA5 →	+1.008	+0.085	<.001	.005	3	5
COAD	FBXL7 →	+0.446	+0.046	<.001	.002	3	5
BRCA	ZNF521 →	+0.757	+0.242	.004	.006	3	5
COAD	SCARF2 →	+0.814	+0.069	<.001	.001	3	5
OV	TCF7L1 →	+1.175	+0.173	.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905522 vs PLPP3 — GBM

Explore this scatter interactively →