Negative regulation of macrophage migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage migration pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCIF1, SLC16A14, and MTG2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage migration activity versus PCIF1 in CNS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PCIF1 →	+0.517	+0.423	.008	.002	3	2
CNS	SLC16A14 →	-1.750	-0.522	.004	<.001	3	2
CNS	MTG2 →	+0.511	+0.330	.004	.003	3	1
CNS	SEC23B →	+0.875	+0.380	.001	.002	3	1
CNS	RPRD1B →	+0.600	+0.313	.006	.001	3	1
CNS	DHX35 →	+0.430	+0.373	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905522 vs PCIF1 — CNS

Explore this scatter interactively →