Regulation of macrophage migration

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESS2, HIRA, and THAP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage migration activity versus ESS2 in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESS2 →	+0.669	+0.239	<.001	.001	3	8
LIVER	HIRA →	+1.077	+0.267	<.001	.001	3	7
LARGE_INTESTINE	THAP7 →	+0.802	+0.212	<.001	.003	3	6
LARGE_INTESTINE	CABIN1 →	+0.976	+0.260	.008	.001	3	6
URINARY_TRACT	EIF4ENIF1 →	+1.011	+0.323	.003	.001	3	5
URINARY_TRACT	AKAP11 →	+0.858	+0.229	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905521 vs ESS2 — LARGE_INTESTINE

Explore this scatter interactively →