Macrophage migration

Across TCGA patient cohorts, RNA activity of the Macrophage migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE3, CEACAM4, and CSF3R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage migration activity versus ADGRE3 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE3 →	+0.773	+0.263	<.001	<.001	3	7
LSCC	CEACAM4 →	+0.665	+0.174	<.001	<.001	3	6
COAD	CSF3R →	+1.082	+0.138	<.001	.001	3	6
COAD	C3 →	+1.069	+0.137	<.001	<.001	3	6
LSCC	TNFSF14 →	+0.659	+0.233	<.001	<.001	3	6
OV	PIK3R5 →	+0.842	+0.284	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905517 vs ADGRE3 — LSCC

Explore this scatter interactively →