Protein localization to microtubule organizing center

Across TCGA patient cohorts, RNA activity of the Protein localization to microtubule organizing center pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF687_S1191, EPB41L2_S614, and NUP35_T273, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to microtubule organizing center activity versus ZNF687_S1191 in OV (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF687_S1191 →	+0.589	+0.373	<.001	.001	2	5
PDAC	EPB41L2_S614 →	-0.952	-0.348	<.001	<.001	3	4
OV	NUP35_T273 →	+0.559	+0.399	<.001	<.001	3	4
OV	CEP131_S78 →	+1.102	+0.474	<.001	<.001	3	4
LUAD	PCM1 →	+0.310	+0.465	<.001	<.001	3	4
LUAD	HIRIP3_T84 →	+0.415	+0.522	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905508 vs ZNF687_S1191 — OV

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