Protein localization to microtubule organizing center

Across TCGA cell cohorts, RNA activity of the Protein localization to microtubule organizing center pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R13L, MREG, and ITGAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R13L grouped by Protein localization to microtubule organizing center-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPP1R13L →	+1.464	+0.732	<.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	MREG →	+0.669	+0.262	.007	.007	3	3
UPPER_AERODIGESTIVE_TRACT	ITGAL →	+0.162	+0.271	.002	<.001	2	4
CNS	IQSEC2 →	-1.284	-0.929	.004	.009	3	3
CNS	IER5L →	-1.583	-0.913	.006	.007	3	3
CNS	NOTCH4 →	-0.561	-0.752	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R13L by Protein localization to microtubule organizing center activity — LUNG_NSCLC_LUAD

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