Protein localization to microtubule organizing center

Across TCGA cell cohorts, RNA activity of the Protein localization to microtubule organizing center pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RWDD2A, RAVER1, and SMARCC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to microtubule organizing center activity versus RWDD2A in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RWDD2A →	+0.431	+0.731	.001	.003	3	4
LIVER	RAVER1 →	+1.360	+1.321	.002	.005	3	4
PANCREAS	SMARCC2 →	+0.832	+0.980	.005	.002	3	4
BLOOD_Leukemia	SLC22A23 →	+1.173	+0.686	.001	<.001	3	4
OVARY	CDK8 →	-0.559	-0.945	.001	.001	3	3
BREAST	PROCR →	-1.786	-0.742	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905508 vs RWDD2A — LUNG_SCLC

Explore this scatter interactively →