Positive regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDHB8, ERBB2, and GLUD2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCDHB8 grouped by Positive regulation of protein localization to membrane-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PCDHB8 →	-0.121	-0.211	.009	.009	3	3
UPPER_AERODIGESTIVE_TRACT	ERBB2 →	-0.190	-0.224	.002	.002	3	3
UPPER_AERODIGESTIVE_TRACT	GLUD2 →	-0.130	-0.253	<.001	.004	3	3
LUNG_NSCLC_LUAD	GPR68 →	-0.118	-0.471	.004	.009	3	3
URINARY_TRACT	ARFGAP2 →	+0.186	+0.291	.009	.001	3	3
LUNG_NSCLC_LUAD	RBM22 →	-0.425	-0.507	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCDHB8 by Positive regulation of protein localization to membrane activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →