Positive regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT3, AFDN, and CEP112, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GALNT3 grouped by Positive regulation of protein localization to membrane-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GALNT3 →	+2.538	+0.864	.001	.001	3	4
LUNG_NSCLC_LUAD	AFDN →	+0.867	+0.719	<.001	.002	3	4
BREAST	CEP112 →	-1.625	-0.790	<.001	.001	3	4
KIDNEY	GGT1 →	-2.333	-1.333	.004	.001	3	3
STOMACH	JAK3 →	+0.608	+0.351	<.001	<.001	3	3
STOMACH	RNF34 →	-0.665	-0.261	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GALNT3 by Positive regulation of protein localization to membrane activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →