Positive regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR2B, ITGB1, and ANXA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to membrane activity versus ACVR2B in STOMACH (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACVR2B →	-1.248	-0.312	<.001	<.001	3	8
SKIN	ITGB1 →	+0.868	+0.190	.001	<.001	3	8
BONE	ANXA2 →	+1.854	+0.371	.001	<.001	3	7
LIVER	ITGA3 →	+5.020	+0.293	<.001	<.001	3	7
PANCREAS	TNFRSF12A →	+1.467	+0.167	.004	.001	3	7
LARGE_INTESTINE	ZNF589 →	-0.856	-0.189	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905477 vs ACVR2B — STOMACH

Explore this scatter interactively →