Negative regulation of protein localization to membrane

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, ARHGAP25, and UBR5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to membrane activity versus AIF1 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AIF1 →	+0.776	+0.067	<.001	<.001	3	9
LSCC	ARHGAP25 →	+0.382	+0.064	.001	<.001	3	9
LSCC	UBR5 →	-0.187	-0.048	<.001	<.001	3	8
BRCA	SERPINB9 →	+0.455	+0.034	.002	.008	3	8
BRCA	SNX2 →	+0.199	+0.031	.001	.003	3	8
OV	TOP1 →	-0.292	-0.049	.002	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905476 vs AIF1 — OV

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