Negative regulation of protein localization to membrane

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, ATP7A, and HMGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to membrane activity versus GINS1 in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS1 →	-0.615	-0.167	<.001	<.001	3	4
LUAD	ATP7A →	+0.264	+0.138	.009	.001	3	4
LSCC	HMGA1 →	-0.635	-0.187	.003	.007	3	4
LUAD	E2F1 →	-0.737	-0.175	<.001	<.001	3	4
UCEC	MR1 →	+0.479	+0.208	.009	<.001	3	4
LUAD	PLK1 →	-0.445	-0.129	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905476 vs GINS1 — LUAD

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