Negative regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, COQ10B, and PPM1M, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to membrane activity versus RPL3 in LARGE_INTESTINE (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPL3 →	-0.827	-0.329	.001	<.001	3	6
PANCREAS	COQ10B →	-0.623	-0.243	.001	.002	3	5
PANCREAS	PPM1M →	-0.913	-0.239	.004	<.001	3	5
PANCREAS	IRX5 →	-0.699	-0.211	.005	<.001	3	5
LUNG_NSCLC_LUSC	OVGP1 →	-0.658	-0.269	.006	<.001	3	5
BLOOD_Leukemia	IQCK →	-0.594	-0.164	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905476 vs RPL3 — LARGE_INTESTINE

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