Regulation of protein localization to membrane

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK1, PHKB, and CHMP3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to membrane activity versus MAPK1 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAPK1 →	+0.909	+0.230	.006	.001	3	2
OV	PHKB →	+0.887	+0.191	.001	.001	3	2
BRCA	CHMP3 →	+0.612	+0.293	.009	.002	3	2
BRCA	PRRG2 →	+2.285	+0.270	.002	.003	3	2
BRCA	KCNH1 →	+1.970	+0.280	.007	.003	3	2
BRCA	EXOC6B →	+0.885	+0.253	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905475 vs MAPK1 — BRCA

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