Regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL2, ZNF584, and AGFG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL2 grouped by Regulation of protein localization to membrane-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARL2 →	-1.240	-0.373	.003	.001	3	5
BREAST	ZNF584 →	-0.949	-0.140	<.001	.003	3	4
LARGE_INTESTINE	AGFG2 →	+0.873	+0.133	.005	.001	3	4
OVARY	LSR →	+2.181	+0.513	.002	.007	3	4
PANCREAS	LIPG →	+2.516	+0.256	.001	<.001	3	4
OESOPHAGUS	CCDC120 →	+1.178	+0.145	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL2 by Regulation of protein localization to membrane activity — BLOOD_Lymphoma

Explore this box plot interactively →