Regulation of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM117B, LRPPRC, and ATXN7L2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to membrane activity versus FAM117B in BONE (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FAM117B →	-1.210	-0.342	<.001	<.001	3	9
SOFT_TISSUE	LRPPRC →	-1.065	-0.258	<.001	.002	2	9
LIVER	ATXN7L2 →	-1.350	-0.230	.002	.002	3	8
BONE	COQ8A →	-1.446	-0.400	<.001	.001	3	8
CNS	GNL3 →	-0.734	-0.205	.006	.007	3	8
BONE	SDC4 →	+2.576	+0.297	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905475 vs FAM117B — BONE

Explore this scatter interactively →