Positive regulation of vascular associated smooth muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1E1, VTN, and OAZ1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell apoptotic process activity versus ATP6V1E1 in GBM (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP6V1E1 →	-0.251	-0.175	.004	.005	3	3
UCEC	VTN →	+0.384	+0.080	.001	.003	3	3
LUAD	OAZ1 →	-0.228	-0.161	.003	.003	3	2
LUAD	TXNDC17 →	-0.478	-0.110	<.001	.008	3	2
LUAD	TMEM128 →	-0.237	-0.144	.006	.003	3	2
LUAD	C17orf64 →	-0.194	-0.113	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905461 vs ATP6V1E1 — GBM

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