Positive regulation of vascular associated smooth muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, PPWD1, and STX18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Positive regulation of vascular associated smooth muscle cell apoptotic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TEAD1 →	-0.383	-0.143	.004	<.001	3	5
BREAST	PPWD1 →	+0.341	+0.091	.002	.005	3	5
URINARY_TRACT	STX18 →	+0.692	+0.357	.006	<.001	3	4
STOMACH	SHOX →	-0.182	-0.162	.001	.001	3	4
SOFT_TISSUE	PPP3R2 →	-0.265	-0.098	<.001	.001	3	4
OESOPHAGUS	GPR61 →	-0.156	-0.118	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Positive regulation of vascular associated smooth muscle cell apoptotic process activity — CNS

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