Negative regulation of vascular associated smooth muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, PPP1R12A_S618, and WDR75, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell apoptotic process activity versus SMC2 in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	+0.667	+0.125	<.001	<.001	3	7
LSCC	PPP1R12A_S618 →	-0.981	-0.128	<.001	<.001	3	7
BRCA	WDR75 →	+0.237	+0.081	<.001	<.001	3	7
LSCC	PPP1R12C →	-0.287	-0.098	<.001	<.001	3	7
BRCA	GNPDA2 →	-0.350	-0.079	<.001	<.001	3	7
BRCA	MYBBP1A_S1267 →	+0.512	+0.087	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905460 vs SMC2 — LSCC

Explore this scatter interactively →