Negative regulation of vascular associated smooth muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA2, BIRC5, and KIF18A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell apoptotic process activity versus KPNA2 in HNSC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KPNA2 →	+1.035	+0.548	.001	.001	3	10
BRCA	BIRC5 →	+1.160	+0.739	<.001	<.001	3	9
HNSC	KIF18A →	+1.113	+0.449	<.001	.004	3	9
LSCC	CLSPN →	+0.871	+0.618	<.001	<.001	3	9
LUAD	CCNB1 →	+1.161	+0.658	<.001	<.001	3	8
BRCA	CCNB2 →	+1.088	+0.458	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905460 vs KPNA2 — HNSC

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