Regulation of lymphoid progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of lymphoid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLCN, MAT2A, and BTBD7, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphoid progenitor cell differentiation activity versus FLCN in THYM (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	FLCN →	+1.050	+0.101	<.001	<.001	3	34
KICH	MAT2A →	+1.326	+0.056	<.001	<.001	3	33
THYM	BTBD7 →	+1.032	+0.100	<.001	<.001	3	32
UVM	SMG1 →	+1.406	+0.109	<.001	<.001	3	32
THYM	ASH1L →	+1.448	+0.095	<.001	<.001	3	32
THYM	APAF1 →	+1.539	+0.091	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905456 vs FLCN — THYM

Explore this scatter interactively →