Regulation of lymphoid progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of lymphoid progenitor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, NRDC, and SEPTIN8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphoid progenitor cell differentiation activity versus EIF3G in BRCA (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EIF3G →	-0.183	-0.053	<.001	<.001	3	6
COAD	NRDC →	-0.190	-0.057	.006	<.001	3	6
OV	SEPTIN8 →	+0.325	+0.045	.008	.009	3	5
BRCA	RSU1 →	+0.294	+0.044	<.001	<.001	3	5
BRCA	SEPTIN11 →	+0.284	+0.040	<.001	<.001	3	5
BRCA	SRP68 →	-0.211	-0.039	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905456 vs EIF3G — BRCA

Explore this scatter interactively →