Regulation of lymphoid progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of lymphoid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGPD5, RPL10AP2, and PRDX1P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphoid progenitor cell differentiation activity versus RGPD5 in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RGPD5 →	+0.179	+0.610	.003	.002	3	4
BRCA	RPL10AP2 →	+1.139	+0.773	.001	.001	3	4
BRCA	PRDX1P1 →	+0.876	+0.711	.001	.004	3	4
BRCA	HNRNPA1P48 →	+0.441	+0.889	.008	.001	3	4
BRCA	RPL26P19 →	+0.887	+0.759	.001	.001	3	4
HNSC	RPL10AP6 →	+0.926	+0.509	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905456 vs RGPD5 — BRCA

Explore this scatter interactively →