Regulation of lymphoid progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lymphoid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTG2, GNG11, and SCAI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTG2 grouped by Regulation of lymphoid progenitor cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BTG2 →	+2.938	+1.411	.006	.007	3	4
CNS	GNG11 →	-1.242	-0.851	.002	.001	3	4
BONE	SCAI →	+0.939	+1.950	<.001	.002	3	4
URINARY_TRACT	FZD5 →	+1.278	+1.411	.006	.007	3	3
URINARY_TRACT	RNF168 →	+0.931	+1.889	<.001	<.001	3	3
PANCREAS	SNX3 →	-0.976	-1.111	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTG2 by Regulation of lymphoid progenitor cell differentiation activity — URINARY_TRACT

Explore this box plot interactively →