Regulation of lymphoid progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lymphoid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPZL3, SH2D3A, and SLC26A10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphoid progenitor cell differentiation activity versus MPZL3 in PANCREAS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MPZL3 →	+2.176	+0.268	.002	.008	3	4
PANCREAS	SH2D3A →	+4.346	+0.233	<.001	.006	3	3
PANCREAS	SLC26A10 →	-1.870	-0.268	.001	.008	3	3
PANCREAS	MPZL2 →	+5.356	+0.239	<.001	.001	3	3
LUNG_SCLC	FAM124A →	-1.315	-0.190	.001	.003	2	4
PANCREAS	RCE1 →	+0.649	+0.268	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905456 vs MPZL3 — PANCREAS

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