Protein localization to presynapse

Across TCGA patient cohorts, RNA activity of the Protein localization to presynapse pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP9, RELCH, and SND1_S645, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to presynapse activity versus FKBP9 in GBM (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FKBP9 →	-0.413	-0.070	<.001	<.001	3	6
GBM	RELCH →	+0.180	+0.089	<.001	<.001	3	5
BRCA	SND1_S645 →	-0.724	-0.096	<.001	<.001	3	5
GBM	COQ6 →	+0.278	+0.099	.002	.001	3	5
GBM	IKBIP →	-0.698	-0.128	<.001	<.001	3	5
LSCC	CEP170 →	-0.246	-0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905383 vs FKBP9 — GBM

Explore this scatter interactively →