Protein localization to presynapse

Across TCGA cell cohorts, RNA activity of the Protein localization to presynapse pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK8IP3, KIF5A, and MAP1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPK8IP3 grouped by Protein localization to presynapse-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAPK8IP3 →	-0.385	-1.306	<.001	<.001	3	8
SOFT_TISSUE	KIF5A →	-0.308	-1.581	.001	<.001	3	7
PANCREAS	MAP1A →	-0.390	-1.471	.008	.005	3	7
LARGE_INTESTINE	HSPB1 →	-0.292	-1.274	<.001	<.001	3	6
LARGE_INTESTINE	GJA8 →	-0.123	-0.850	.008	.002	3	5
BONE	TOR1A →	-0.250	-1.973	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPK8IP3 by Protein localization to presynapse activity — BREAST

Explore this box plot interactively →