Protein localization to presynapse

Across TCGA cell cohorts, RNA activity of the Protein localization to presynapse pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATAD2B, PAPOLG, and DNM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATAD2B grouped by Protein localization to presynapse-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GATAD2B →	+0.801	+1.474	<.001	.001	3	5
LUNG_NSCLC_LUSC	PAPOLG →	+0.944	+1.735	.009	<.001	3	4
BREAST	DNM1 →	+1.522	+1.001	.009	.004	3	4
LARGE_INTESTINE	GNMT →	+0.235	+1.142	.003	<.001	3	4
LARGE_INTESTINE	ZNF718 →	+0.962	+1.150	.006	.001	3	4
BLOOD_Leukemia	CCDC77 →	+0.602	+0.843	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATAD2B by Protein localization to presynapse activity — BONE

Explore this box plot interactively →