Protein localization to presynapse

Across TCGA cell cohorts, RNA activity of the Protein localization to presynapse pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB1, ACBD5, and ATP6V1E1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to presynapse activity versus HSPB1 in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HSPB1 →	+2.340	+0.324	.001	.005	3	7
SKIN	ACBD5 →	+0.505	+0.186	.004	.009	3	5
LUNG_SCLC	ATP6V1E1 →	+0.410	+0.195	.008	.005	3	5
SOFT_TISSUE	TINAGL1 →	-3.876	-0.492	<.001	.004	3	5
CNS	TFRC →	-0.752	-0.235	.004	<.001	3	5
SOFT_TISSUE	CALM3 →	+0.751	+0.368	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905383 vs HSPB1 — BLOOD_Lymphoma

Explore this scatter interactively →