Regulation of snRNA transcription by RNA polymerase II

Across TCGA patient cohorts, RNA activity of the Regulation of snRNA transcription by RNA polymerase II pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CC2D1A, CDK17_S137, and MISP3_S208, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of snRNA transcription by RNA polymerase II activity versus CC2D1A in HNSC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CC2D1A →	+0.192	+0.075	<.001	<.001	3	6
PDAC	CDK17_S137 →	-0.259	-0.064	<.001	<.001	3	5
LUAD	MISP3_S208 →	+1.019	+0.068	<.001	<.001	3	5
COAD	CDC27 →	-0.189	-0.029	<.001	<.001	3	4
HNSC	CC2D1A_S455 →	+0.487	+0.114	<.001	<.001	3	4
HNSC	CC2D1A_T120 →	+0.287	+0.084	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905380 vs CC2D1A — HNSC

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