Regulation of snRNA transcription by RNA polymerase II

Across TCGA patient cohorts, RNA activity of the Regulation of snRNA transcription by RNA polymerase II pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, LMOD1, and ASF1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of snRNA transcription by RNA polymerase II activity versus MSRB3 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSRB3 →	-0.629	-0.194	.002	.003	3	5
HNSC	LMOD1 →	-0.737	-0.170	.001	<.001	3	5
GBM	ASF1B →	+0.722	+0.225	.005	<.001	3	4
LSCC	PLA2G5 →	-0.350	-0.152	.002	.004	3	4
HNSC	PTH1R →	-0.487	-0.145	.002	<.001	3	4
LSCC	MYL3 →	-0.185	-0.200	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905380 vs MSRB3 — LSCC

Explore this scatter interactively →