Positive regulation of morphogenesis of an epithelium

Across TCGA patient cohorts, RNA activity of the Positive regulation of morphogenesis of an epithelium pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GJA1, GJA1_S255, and GJA1_S279, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of morphogenesis of an epithelium activity versus GJA1 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GJA1 →	+0.812	+0.246	<.001	<.001	3	4
OV	GJA1_S255 →	+1.214	+0.586	<.001	.005	2	5
LSCC	GJA1_S279 →	+0.753	+0.632	<.001	.001	3	4
LSCC	GJA1_S297 →	+1.449	+0.857	<.001	<.001	3	4
OV	ATRX_S1527 →	-1.013	-0.577	<.001	<.001	3	3
OV	EML4_S184 →	+1.001	+0.588	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905332 vs GJA1 — GBM

Explore this scatter interactively →