Positive regulation of morphogenesis of an epithelium

Across TCGA cell cohorts, RNA activity of the Positive regulation of morphogenesis of an epithelium pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB32, RAP1GAP2, and UCK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB32 grouped by Positive regulation of morphogenesis of an epithelium-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB32 →	-1.998	-0.613	<.001	.008	3	5
BLOOD_Lymphoma	RAP1GAP2 →	+2.435	+1.623	.001	.008	2	6
SKIN	UCK1 →	-0.538	-0.933	.002	.001	3	4
SKIN	STX11 →	-1.256	-0.849	.003	.005	3	4
LUNG_NSCLC_LUAD	CTSL →	-1.233	-0.401	.009	.008	2	5
LUNG_SCLC	CDH1 →	+3.982	+0.381	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB32 by Positive regulation of morphogenesis of an epithelium activity — BREAST

Explore this box plot interactively →