Negative regulation of morphogenesis of an epithelium

Across TCGA patient cohorts, RNA activity of the Negative regulation of morphogenesis of an epithelium pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX2, VSTM4, and GSTM5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of morphogenesis of an epithelium activity versus TBX2 in OV (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TBX2 →	+1.060	+0.745	<.001	<.001	2	7
BRCA	VSTM4 →	+0.676	+0.747	.004	<.001	3	6
LUAD	GSTM5 →	+0.365	+0.503	.005	.007	3	5
BRCA	LAMA2 →	+0.934	+0.609	<.001	.001	3	5
BRCA	PRKG1 →	+0.657	+0.719	.002	.001	3	5
LUAD	LTBP2 →	+0.799	+0.545	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905331 vs TBX2 — OV

Explore this scatter interactively →