Regulation of morphogenesis of an epithelium

Across TCGA cell cohorts, RNA activity of the Regulation of morphogenesis of an epithelium pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH1, GALNT3, and CDS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of morphogenesis of an epithelium activity versus CDH1 in PANCREAS (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CDH1 →	+4.714	+1.930	<.001	<.001	3	10
PANCREAS	GALNT3 →	+4.307	+1.638	<.001	<.001	3	10
PANCREAS	CDS1 →	+2.902	+1.989	<.001	<.001	3	9
OVARY	CDH3 →	+3.936	+1.190	<.001	.003	3	9
URINARY_TRACT	CAPN1 →	+1.318	+1.015	.003	.009	3	9
STOMACH	LSR →	+2.190	+1.010	.009	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905330 vs CDH1 — PANCREAS

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